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Learn more about important topics related to advanced breast cancer. Watch this space for more hubs in the future.
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ADVANCED BREAST CANCER INFORMATION

25% of all cancers in women are breast cancer
25% of all cancers diagnosed in women are breast cancer
80% of breast cancers in developing countries are diagnosed at the metastatic stage
80% of breast cancers in developing countries are diagnosed at the metastatic stage
20-30% of early breast cancer cases will relapse even with the best possible treatments
20-30% of early breast cancer cases will relapse even with the best possible treatments
2-3 years median survival for patients with ABC, and this has not changed significantly in decades
2-3 years: the median survival for patients with ABC, and this has not changed significantly in decades

Breast cancer is the most diagnosed cancer in women worldwide, with 2.3 million women diagnosed with breast cancer in 20201. Almost 700 000 people worldwide died from breast cancer in 2020, the majority of whom with advanced disease1. Breast cancer occurs when abnormal cells in the breast multiply uncontrollably to form a tumour. While most cases of breast cancer occur in women it does occur in men too, although this is rare (about 1% of cases)2.Breast cancer which has spread to other parts of the body is referred to as metastatic or advanced breast cancer. Common sites for metastatic tumours to grow are the bones, lymph nodes, lungs, and liver, meaning that signs and symptoms of the disease can vary greatly in each patient3. Advanced Breast Cancer (ABC) comprises inoperable Locally Advanced Breast Cancer (LABC) and Metastatic Breast Cancer (MBC). MBC is also known as stage IV or secondary breast cancer4.

Treatment for the disease can include chemotherapy, endocrine therapy, biological therapy, radiation and in some cases also surgery5. Advanced and metastatic breast cancer is currently incurable, but treatable, with a median survival rate of 2-3 years, although variable according to the subtype of ABC6.

New technologies should help to accelerate advances in treatment.

With the advances in science, technology and communication tools, it is imperative that the cancer community around the globe joins forces to raise awareness of the disease and lobby for better outcomes for people living with ABC6.

The ABC Global Alliance aim is to improve and extend the lives of women and men living with ABC in all countries worldwide and to fight for a cure.

References:

  1. Globocan 2020, Available at https://gco.iarc.fr/today/home [Accessed 18 August 2022]
  2. American Cancer Society. What are the Key Statistics About Breast Cancer in Men. Available at: https://www.cancer.org/cancer/breast-cancer-in-men/about/key-statistics.html [Accessed 24 February 2017]
  3. Cancer Research UK. Symptoms of Advanced Breast Cancer. Available at: http://www.cancerresearchuk.org/about-cancer/breast-cancer/advanced/symptoms [Accessed 1 March 2017]
  4. Cardoso et al. 2014. ESO-ESMO 2nd international consensus guidelines for advanced breast cancer (ABC2). Annals of Oncology 25 (1871-1888)
  5. Cancer Research UK. Breast Cancer Treatment. Available at http://www.cancerresearchuk.org/about-cancer/breast-cancer/treatment [Last accessed 07 April 2017]
  6. F. Cardoso, et al. ESO-ESMO 5th International Consensus Guidelines for Advanced Breast Cancer (ABC 5). Published in Annals of Oncology (Annals of Oncology, volume 31, issue 12, September 2020, DOI:https://doi.org/10.1016/j.annonc.2020.09.010)